The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis | Zendy

Nathan P. Wiederhold | Zendy; Laura K. Najvar | Zendy; Rosie Jaramillo | Zendy; Marcos Olivo | Zendy; Michael Birch | Zendy; Derek Law | Zendy; John Rex | Zendy; Gabriel Catano | Zendy; Thomas F. Patterson | Zendy

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The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis

Author(s) -

Nathan P. Wiederhold,

Laura K. Najvar,

Rosie Jaramillo,

Marcos Olivo,

Michael Birch,

Derek Law,

John Rex,

Gabriel Catano,

Thomas F. Patterson

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00999-18

Subject(s) - coccidioides , fluconazole , coccidioides immitis , in vivo , biology , mycosis , in vitro , medicine , pharmacology , microbiology and biotechnology , immunology , antifungal , biochemistry

Olorofim (formerly F901318) is an advanced analog of the orotomide class that inhibits fungal pyrimidine biosynthesis. We evaluated thein vitro andin vivo activities of olorofim againstCoccidioides species.

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