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This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.

antimicrobial agents and chemotherapy

Comparative Efficacies of Two Antimony Regimens To Treat <i>Leishmania braziliensis</i> -Induced Cutaneous Leishmaniasis in Rhesus Macaques ( <i>Macaca mulatta</i> )

Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis -Induced Cutaneous Leishmaniasis in Rhesus Macaques ( Macaca mulatta )