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β-Lactam-resistantHaemophilus influenzae is a clinical concern. A high prevalence (&gt;40%) of β-lactamase-negative high-level ampicillin-resistantH. influenzae (high-BLNAR) isolates in Japan has been reported.

antimicrobial agents and chemotherapy

Multiclonal Expansion and High Prevalence of β-Lactamase-Negative Haemophilus influenzae with High-Level Ampicillin Resistance in Japan and Susceptibility to Quinolones