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Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potentin vitro activity againstStaphylococcus aureus andPseudomonas aeruginosa , two important causes of keratitis. Here we further characterize this combination againstP. aeruginosa in a murine keratitis model.

A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections