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The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P &lt; 0.05) than against conidia (10%). Antagonism was not observed.

Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro