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Sequence variation in the asparagine/aspartate-rich domain ofpfmdr1 in 215 isolates ofPlasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. Thepfmdr1 86Y allele was significantly associated with different configurations of the Asn/Asp-rich domain in West and East Africa. In Kenya, a specific form of the Asn/Asp-rich domain was significantly linked to the 86Y, 184Y, and 1246Y haplotype ofpfmdr1 .

antimicrobial agents and chemotherapy

The Polymorphic Linker Domain of <i>pfmdr1</i> Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa