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Ourin vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those withCladophialophora carrionii ,Cladophialophora arxii ,Exophiala dermatitidis ,Exophiala spinifera ,Fonsecaea monophora ,Fonsecaea nubica ,Fonsecaea pedrosoi , andPhialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species ofFonsecaea andCladophialophora .

Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis