Open AccessGenetic Characterization and Emergence of the Metallo-β-Lactamase GIM-1 in Pseudomonas spp. and Enterobacteriaceae during a Long-Term Outbreak
Author(s) -
Andreas Wendel,
Alexander H. B. Brodner,
Stephan Wydra,
Sofija Ressina,
Birgit Henrich,
Klaus Pfeffer,
Mark A. Toleman,
Colin R. MacKenzie
Publication year - 2013
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00118-13
Subject(s) - klebsiella oxytoca , citrobacter freundii , enterobacter cloacae , enterobacteriaceae , microbiology and biotechnology , serratia marcescens , biology , citrobacter , enterobacter , outbreak , klebsiella , escherichia coli , virology , genetics , gene
Since the first isolation in 2002, the metallo-β-lactamase GIM-1 has not been detected outside Germany. The data presented here, for 50 clinical blaGIM-1-positive isolates, including Pseudomonas spp. and Enterobacteriaceae (Enterobacter cloacae, Klebsiella oxytoca, Serratia marcescens, Escherichia coli, and Citrobacter freundii), collected between 2007 and 2012 at the original site in an ongoing outbreak, demonstrate a diverse genetic background and dissemination of the gene conferring resistance to enteric bacteria.
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