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We compared the pharmacokinetics and efficacy of a combination ofd -cycloserine (DCS) and ethionamide (ETO) via oral and inhalation routes in mice. The plasma half-life (t 1/2 ) of oral ETO at a human-equivalent dose decreased from 4.63 ± 0.61 h to 1.64 ± 0.40 h when DCS was coadministered.

antimicrobial agents and chemotherapy

Preclinical Development of Inhalable <scp>d</scp> -Cycloserine and Ethionamide To Overcome Pharmacokinetic Interaction and Enhance Efficacy against <i>Mycobacterium tuberculosis</i>

Preclinical Development of Inhalable d -Cycloserine and Ethionamide To Overcome Pharmacokinetic Interaction and Enhance Efficacy against Mycobacterium tuberculosis