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Mutations in genes encoding zinc cluster transcription factors (ZCFs) such asTAC1 ,MRR1 , andUPC2 play a key role inCandida albicans azole antifungal resistance. Artificial activation of the ZCF Mrr2 has shown increased expression of the gene encoding the Cdr1 efflux pump and resistance to fluconazole.

antimicrobial agents and chemotherapy

Contribution of Clinically Derived Mutations in the Gene Encoding the Zinc Cluster Transcription Factor Mrr2 to Fluconazole Antifungal Resistance and <i>CDR1</i> Expression in <i>Candida albicans</i>

Contribution of Clinically Derived Mutations in the Gene Encoding the Zinc Cluster Transcription Factor Mrr2 to Fluconazole Antifungal Resistance and CDR1 Expression in Candida albicans