Open AccessCommensal bacteria contribute to insulin resistance in aging by activating innate B1a cells
Author(s) -
Monica Bodogai,
Jennifer O’Connell,
Ki H. Kim,
Yoo Kim,
Kanako Moritoh,
Chen Chen,
Fedor Gusev,
Kelli L. Vaughan,
Natalia Shulzhenko,
Julie A. Mattison,
Catalina Lee-Chang,
Weixuan Chen,
Olga D. Carlson,
Kevin G. Becker,
Manoj Gurung,
Andrey Morgun,
James R. White,
Theresa Meade,
Kathy A Perdue,
Matthias Mack,
Luigi Ferrucci,
Giorgio Trinchieri,
Rafael de Cabo,
Е. И. Рогаев,
Josephine M. Egan,
Jiejun Wu,
Arya Biragyn
Publication year - 2018
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aat4271
Subject(s) - insulin resistance , innate immune system , monocyte , bacteria , insulin , biology , microbiology and biotechnology , immunology , endocrinology , immune system , genetics
The increase of insulin resistance in “healthy” aging can be explained by a gut microbiota–monocyte–B1a B cell axis.
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