Open AccessSuppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma
Author(s) -
Liran Zhou,
Hongmei Husted,
Todd T. Moore,
Mason Lu,
Defeng Deng,
Yan Liu,
Vijaya Ramachandran,
Thiruvengadam Arumugam,
Christof Niehrs,
Huamin Wang,
Paul J. Chiao,
Jianhua Ling,
Michael A. Curran,
Anirban Maitra,
MienChie Hung,
Jeffrey E. Lee,
Craig D. Logsdon,
Rosa F. Hwang
Publication year - 2018
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aat3487
Subject(s) - stromal cell , stroma , pancreatic ductal adenocarcinoma , cancer research , tumor progression , pancreatic cancer , medicine , adenocarcinoma , pathology , oncology , cancer , immunohistochemistry
DKK3 is produced by the stroma in pancreatic cancer, promotes tumor progression and resistance to therapy, and is a therapeutic target.
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