Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis | Zendy

Changyu Zhu | Zendy; KyeongJin Kim | Zendy; Xiaobo Wang | Zendy; Alberto Bartolomé | Zendy; Marcela Salomao | Zendy; Paola Dongiovanni | Zendy; Marica Meroni | Zendy; Mark J. Graham | Zendy; Katherine P. Yates | Zendy; Anna Mae Diehl | Zendy; Robert F. Schwabe | Zendy; Ira Tabas | Zendy; Luca Valenti | Zendy; Joel E. Lavine | Zendy; Utpal B. Pajvani | Zendy

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Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Author(s) -

Changyu Zhu,

KyeongJin Kim,

Xiaobo Wang,

Alberto Bartolomé,

Marcela Salomao,

Paola Dongiovanni,

Marica Meroni,

Mark J. Graham,

Katherine P. Yates,

Anna Mae Diehl,

Robert F. Schwabe,

Ira Tabas,

Luca Valenti,

Joel E. Lavine,

Utpal B. Pajvani

Publication year - 2018

Publication title -

science translational medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aat0344

Subject(s) - fibrosis , hepatocyte , steatohepatitis , nonalcoholic fatty liver disease , cirrhosis , medicine , fatty liver , liver function , liver disease , pathology , biology , endocrinology , disease , biochemistry , in vitro

Aberrant hepatocyte Notch activation is required for development of NASH-associated fibrosis, and Notch inhibition ameliorates obesity-induced liver disease.

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