Open AccessmGlu 7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome
Author(s) -
Rocco G. Gogliotti,
Rebecca K. Senter,
Nicole M. Fisher,
J. Paige Adams,
Rocio Zamorano,
Adam G. Walker,
Anna L. Blobaum,
Darren W. Engers,
Corey R. Hopkins,
J. Scott Daniels,
Carrie K. Jones,
Craig W. Lindsley,
Zixiu Xiang,
P. Jeffrey Conn,
Colleen M. Niswender
Publication year - 2017
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aai7459
Subject(s) - rett syndrome , long term potentiation , neuroscience , phenotype , allosteric regulation , animal model , cognition , medicine , psychology , biology , genetics , receptor , gene
mGlu7 positive allosteric modulation rescues long-term potentiation, learning, and memory phenotypes and prevents apneas in a mouse model of Rett syndrome.
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