Open AccessDelayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome
Author(s) -
Zhantao Yang,
Sioḃán Keel,
Akiko Shimamura,
Li Liu,
Aaron T. Gerds,
Henry Y. Li,
Brent L. Wood,
Bart L. Scott,
Janis L. Abkowitz
Publication year - 2016
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aaf3006
Subject(s) - macrocytic anemia , globin , diamond–blackfan anemia , heme , anemia , hemoglobin , erythropoiesis , medicine , chemistry , cancer research , biochemistry , rna , gene , enzyme , ribosome
When heme synthesis exceeds globin synthesis, red blood cell differentiation fails, resulting in severe anemia.
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