Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes | Zendy

Joshua T. Schiffer | Zendy; David A. Swan | Zendy; Amalia Magaret | Zendy; Lawrence Corey | Zendy; Anna Wald | Zendy; Joachim Ossig | Zendy; Helga RuebsamenSchaeff | Zendy; Susanne Stoelben | Zendy; Burkhard Timmler | Zendy; Holger Zimmermann | Zendy; Murad Melhem | Zendy; Scott A. Van Wart | Zendy; Christopher M. Rubino | Zendy; Alexander Birkmann | Zendy

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Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

Author(s) -

Joshua T. Schiffer,

David A. Swan,

Amalia Magaret,

Lawrence Corey,

Anna Wald,

Joachim Ossig,

Helga RuebsamenSchaeff,

Susanne Stoelben,

Burkhard Timmler,

Holger Zimmermann,

Murad Melhem,

Scott A. Van Wart,

Christopher M. Rubino,

Alexander Birkmann

Publication year - 2016

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aad6654

Subject(s) - herpes simplex virus , clinical trial , selection (genetic algorithm) , virus , virology , medicine , drug , simplex , computer science , pharmacology , mathematics , artificial intelligence , geometry

A mathematical model for antiviral clinical trials improves dose selection and understanding of drug-virus interaction.

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