Open AccessThe E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis
Author(s) -
Jinkuk Choi,
Jie Gao,
Jaekwang Kim,
Cynthia Hong,
Jungsu Kim,
Peter Tontonoz
Publication year - 2015
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aad1904
Subject(s) - ubiquitin ligase , ubiquitin , apolipoprotein e , amyloidosis , chemistry , receptor , medicine , endocrinology , microbiology and biotechnology , biology , biochemistry , gene , disease
Inhibiting the E3 ubiquitin ligase Idol in a mouse model of Alzheimer’s-like pathology ameliorates disease severity by promoting clearance of Aβ peptides by microglia.
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