Open AccessOncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
Author(s) -
Evan C. Lien,
Laura Ghisolfi,
Renee C. Geck,
John M. Asara,
Alex Toker
Publication year - 2017
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aao6604
Subject(s) - methionine , cystine , homocysteine , cysteine , transsulfuration , cystathionine beta synthase , degron , cancer cell , biochemistry , methionine synthase , chemistry , microbiology and biotechnology , msra , biology , cancer research , amino acid , cancer , ubiquitin ligase , ubiquitin , gene , genetics , enzyme
Inhibition of the transporter xCT by oncogenic PI3K mutants contributes to methionine dependency in breast cancer cells.
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