Open AccessmTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2
Author(s) -
Oluseye A. Ogunbayo,
Jingxian Duan,
Jian Xiong,
Qiaochu Wang,
Xinghua Feng,
Jianjie Ma,
Michael X. Zhu,
A. Mark Evans
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1945-0877
pISSN - 1937-9145
DOI - 10.1126/scisignal.aao5775
Subject(s) - mtorc1 , chemistry , microbiology and biotechnology , biophysics , biochemistry , biology , phosphorylation , protein kinase b
The ion channel TPC2 is required for Ca2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.
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