Open AccessSkp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
Author(s) -
Emilie Clement,
Hiroyuki Inuzuka,
Naoe Taira Nihira,
Wenyi Wei,
Alex Toker
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aao3810
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , ubiquitin ligase , cancer research , biology , kinase , signal transduction , mtorc2 , microbiology and biotechnology , ubiquitin , phosphorylation , mtorc1 , biochemistry , gene
Resistance to PI3K inhibitors in triple-negative breast cancer is mediated by AKT reactivation by the ubiquitin ligase Skp2.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom