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The twinning of techniques from biophysics and molecular biology has led to remarkable progress in understanding the molecular mechanisms of synaptic transmission. Here we review the current picture of Ca++-triggered exocytosis, which has emerged from studies of a simple cellular model, the adrenal chromaffin cell. We discuss the molecular players that have been assigned a specific role in a particular step of this process and give a brief outlook on what these insights might tell us about mechanisms of short-term plasticity at classical synapses.

Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis

Emerging Roles of Presynaptic Proteins in Ca ⁺⁺ -Triggered Exocytosis