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Ultrasonic cavitation is being used in medical applications as a way toinfluence matter, such as tissue or drug vehicles, on a micro-scale.Oscillating or collapsing cavitation bubbles provide transient mechanical forcefields, which can, e.g., fractionate soft tissue or even disintegrate solidobjects such as calculi. Our recent study demonstrates that an ultrasonicallyactuated medical needle can create cavitation phenomena inside water. However,the presence and behavior of cavitation and related bioeffects in diagnosticand therapeutic applications with ultrasonically actuated needles are notknown. Using simulations, we demonstrate numerically and experimentally thecavitation phenomena near ultrasonically actuated needles. We define thecavitation onset within a liver tissue model with different total acousticpower levels. We directly visualize and quantitatively characterize cavitationevents generated by the ultrasonic needle in thin fresh bovine liver sectionsenabled by high speed imaging. On a qualitative basis, the numerical andexperimental results show a close resemblance in threshold and spatialdistribution of cavitation. These findings are crucial for developing newmethods and technologies employing ultrasonically actuated fine-needles such asultrasound-enhanced fine-needle biopsy, drug delivery and histotripsy.

An Ultrasonically Actuated Fine-Needle Creates Cavitation in Bovine Liver