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The Infrared Array Camera (IRAC) on the Spitzer Space Telescope has been used to measure < 10-4 temporal variations in point sources (such as transiting extrasolar planets) at 3.6 and 4.5 μm. Due to the under-sampled nature of the PSF, the warm IRAC arrays show variations of as much as 8% in sensitivity as the center of the PSF moves across a pixel due to normal spacecraft pointing wobble and drift. These intra-pixel gain variations are the largest source of correlated noise in IRAC photometry. Usually this effect is removed by fitting a model to the science data themselves (self-calibration), which could result in the removal of astrophysically interesting signals. We describe a new technique for significantly reducing the gain variations and improving photometric precision in a given observation, without using the data to be corrected. This comprises: (1) an adaptive centroiding and repositioning method ("Peak-Up") that uses the Spitzer Pointing Control Reference Sensor (PCRS) to repeatedly position a target to within 0.1 IRAC pixels of an area of minimal gain variation; and (2) the high-precision, high-resolution measurement of the pixel gain structure using non-variable stars. We show that the technique currently allows the reduction of correlated noise by almost an order of magnitude over raw data, which is comparable to the improvement due to self-calibration. We discuss other possible sources of correlated noise, and proposals for reducing their impact on photometric precision.

Intra-pixel gain variations and high-precision photometry with the Infrared Array Camera (IRAC)