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The full-width at half-max (FWHM) criterion is often used for both manual and automatic quantification of the vessel diameter in medical images. The FWHMcriterion is easy to understand and it can be implemented with low computational cost. However, it is well known that the FWHM criterion can give an over- and underestimation of the vessel diameter. In this paper, we propose a simple and original method to create an unbiased estimation of the vessel diameter based on the FWHM criterion and we compared the robustness to noise of several edge detectors. The quantitative results of our experiments show that the proposed method is more accurate and precise than other (more complex) edge detectors, even for small vessels.

Unbiased vessel-diameter quantification based on the FWHM criterion