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Fluid-structure interaction in the developing heart is an active area ofresearch in developmental biology. However, investigation of heart dynamics ismostly limited to computational fluid dynamics simulations using heart wallstructure information only, or single plane blood flow information - so thereis a need for 3D + time resolved data to fully understand cardiac function. Wepresent an imaging platform combining selective plane illumination microscopy(SPIM) with micro particle image velocimetry ({\textmu}PIV) to enable3D-resolved flow mapping in a microscopic environment, free from many of thesources of error and bias present in traditional epifluorescence-based{\textmu}PIV systems. By using our new system in conjunction with optical heartbeat synchronisation, we demonstrte the ability obtain non-invasive 3D + timeresolved blood flow measurements in the heart of a living zebrafish embryo.

4D blood flow mapping using SPIM-microPIV in the developing zebrafish heart