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Photoacoustic (PA) imaging systems based on clinical linear ultrasound arrayshave become increasingly popular in translational PA research. Such systems canbe more easily integrated in a clinical workflow due to the simultaneous accessto ultrasonic imaging and their familiarity of use to clinicians. In contrastto more complex setups, hand held linear probes can be applied to a largevariety of clinical use cases. However, most translational work with suchscanners is based on proprietary development and as such not accessible to thecommunity. In this contribution, we present a custom-built, hybrid,multispectral, real-time photoacoustic and ultrasonic imaging system with alinear array probe that is controlled by software developed within the MedicalImaging Interaction Toolkit (MITK) a highly customizable and extendableopen-source software platform. Our software offers direct control of both thelaser and the ultrasonic system and may serve as a starting point for varioustranslational research projects and developments. To demonstrate theapplicability of the platform, we used it to implement a new method for bloodoxygenation estimation in the presence of non-rigid inter-frame motion causedby pulsing arteries. Initial results from experiments with healthy humanvolunteers demonstrate the suitability of the method with the sample clinicalapplication of imaging the common carotid artery as well as peripheralextremity vessels.

An open-source software platform for translational photoacoustic research and its application to motion-corrected blood oxygenation estimation