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We developed a micro-motor based miniature catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.United States. Air Force Office of Scientific Research (contract FA9550-10-1-0063)United States. Air Force Office of Scientific Research (contract FA9550-10-1-0551)National Institutes of Health (U.S.) (R01-CA075289-15)National Institutes of Health (U.S.) (R44CA101067-06)National Institutes of Health (U.S.) (R01-EY011289-24)National Institutes of Health (U.S.) (R01-NS057476-02)National Institutes of Health (U.S.) (R01EY013516-16)Deutsche Forschungsgemeinschaft (DFG-GSC80-SAOT

Ultrahigh speed endoscopic optical coherence tomography using micro-motor imaging catheter and VCSEL technology