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Photoacoustic imaging can achieve high-resolution three-dimensionalvisualization of optical absorbers at penetration depths ~ 1 cm in biologicaltissues by detecting optically-induced high ultrasound frequencies. Tomographicacquisition with ultrasound linear arrays offers an easy implementation ofsingle-side access, parallelized and high-frequency detection, but usuallycomes with an image quality impaired by the directionality of the detectors.Indeed, a simple translation of the array perpendicularly to its median imagingplane is often used, but results both in a poor resolution in the translationdirection and in strong limited view artifacts. To improve the spatialresolution and the visibility of complex structures while keeping a planardetection geometry, we introduce, in this paper, a novel rotate-translatescanning scheme, and investigate the performance of a scanner implemented at 15MHz center frequency. The developed system achieved a quasi-isotropic uniform3D resolution of ~170 um over a cubic volume of side length 8.5 mm, i.e. animprovement in the resolution in the translation direction by almost one orderof magnitude. Dual wavelength imaging was also demonstrated with ultrafastwavelength shifting. The validity of our approach was shown in vitro. Wediscuss the ability to enable in vivo imaging for preclinical and clinicalstudies.

Single-side access, isotropic resolution and multispectral 3D photoacoustic imaging with rotate-translate scanning of ultrasonic detector array