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In order to understand the relationship between accommodation and vision quality, a custom-built ultra-long scan depth spectral domain optical coherence tomography (UL-SDOCT) and a Shack-Hartmann wavefront sensor (HSWFS) were combined. The resolution and scan depth of UL-SDOCT are 6 μm and 15.6 mm, respectively, which allow for high-resolution imaging of the whole anterior segment. The HSWFS consists of a 32 × 32 microlens array, and is able to measure first 35th-order Zernike aberrations with (1/20)λ measurement accuracy. The integrated system succeeded in measuring the ocular anterior segment dimension parameters and the ocular monochromatic high-order aberrations simultaneously under the conditions of nonaccommodative and accommodative stimuli. This may help understand the regulatory mechanism of image quality control in the human eye.

Measurement of ocular anterior segment dimension and wavefront aberration simultaneously during accommodation