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Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers.Singapore-MIT Alliance (Computational and Systems Biology Flagship Project)Singapore. Agency for Science, Technology and ResearchSingapore. Biomedical Research Council (BMRC R185-001-045-305)Institute of Bioengineering and Nanotechnology (Singapore)Singapore. Ministry of EducationJassen Cilag (Firm) (R-185-000-182- 592)Singapore-MIT Alliance (Computational and Systems Biology Flagship Project) (C-382-603-004-001)Singapore. Mechanobiology InstituteSingapore-MIT Alliance for Research and Technology. BioSystems and Micromechanic

Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy