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Three-dimensional optical coherence tomography 3D- OCT is used to evaluate the structure and pathology of regenerating mouse skeletal muscle autografts for the first time. The death of myo- fibers with associated inflammation and subsequent new muscle for- mation in this graft model represents key features of necrosis and inflammation in the human disease Duchenne muscular dystrophy. We perform 3D-OCT imaging of excised autografts and compare OCT images with coregistered histology. The OCT images readily distin- guish the necrotic and inflammatory tissue of the graft from the intact healthy muscle fibers in the underlying host tissue. These preliminary findings suggest that, with further development, 3D-OCT could be used as a tool for the evaluation of small-animal muscle morphology and pathology, in particular, for analysis of mouse models of muscular dystrophy. © 2008 Society of Photo-Optical Instrumentation Engineers.

Three-dimensional optical coherence tomography of whole-muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice