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Multiphase CFD modelling has been applied to a cubic geometry single-use-technology (SUT) bioreactor as a tool during the design process. A non-cylindrical tank geometry is employed to make the platform more appealing to wider industrial biotechnology applications in terms of cost and simplicity, with mass transfer investigated in terms of kLa values. Five models for the mass transfer coefficient kL are compared for a range of different conditions. The effect of varying the impeller rotational speed is investigated, with an optimum value of 400 RPM identified. Increasing the aeration rate from 0.0675 to 0.1 vvm has also been shown to increase the average kLa values within the vessel by approximately 50%. An existing 1,000 L vessel is modelled, as well as a theoretical 200 L alternative, which showed much improved mass transfer for the same inlet gas velocity. Turbulence is modelled using the k-ε model and impeller motion is modelled using the moving reference frame method.

Multiphase CFD Modelling of Single-Use-Technology Bioreactors for Industrial Biotechnology Applications