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Although the application of aroma–oil compounds contained in plants such as lavender to the skin produces a local anesthetic effect, cellular mechanisms for this effect have not been fully examined yet. Since some of aroma oil–derived chemicals modulate transient receptor potential (TRP) channels expressed in primary–afferent neurons, this modulation may be involved in the local anesthetic effect. We have previously reported that plant–derived chemicals (capsaicin, menthol and allyl isothiocyanate, which activate TRPV1, TRPM8 and TRPA1 channels, respectively) at high concentrations inhibit fast–conducting and Na+–channel blocker tetrodotoxin–sensitive compound action potentials (CAPs) recorded from the frog sciatic nerve without TRP activation. The CAPs were also inhibited by opioids and adrenoceptor agonists without the activation of receptors for the agonists. The inhibitory actions were specific to their chemical structures. The present study examined how various aroma–oil compounds affect frog sciatic nerve CAPs by using the air–gap method. Lavender–oil compounds, linalyl acetate and linalool, reduced CAP peak amplitudes with the half– maximal inhibitory concentration (IC50) values of 0.49 mM and 1.65 mM, respectively. When compared with local anesthetics’ actions reported previously in the frog sciatic nerve, the linalyl acetate activity was similar to those of lidocaine, ropivacaine and cocaine (0.74, 0.34 and 0.80mM, respectively), while the linalool one was comparable to that (2.2mM) of procaine. Citral, which activated TRPV1, TRPM8, TRPA1 and TRPV3 channels, attenuated CAP peak amplitudes with the IC50 value of 0.48 mM; this action was resistant to a non–selective TRP antagonist ruthenium red (0.3 mM). Camphor, a TRPV1 and TRPV3 agonist, also reduced CAP peak amplitudes (by 30% at 5mM) in a manner insensitive to ruthenium red. With respect to other aroma–oil compounds, citronellal and rose oxide reduced CAP peak amplitudes with the IC50 values of 0.50mM and 2.0mM, respectively, while myrcene at a high concentration such as 5 mM hardly reduced CAP peak amplitudes. Taking into consideration previously–reported frog sciatic nerve data, an efficacy sequence of aroma–oil compounds for the CAP

Inhibitory actions of aroma–oil chemicals on compound action potentials in the frog sciatic nerve