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We investigated the influence of granulocyte colony-stimulating factor (G-CSF) on bactericidal activities of macrophages and polymorphonuclear leukocytes (PMNs) from experimental pyelonephritis in leukocytopenic rats, in order to clarify the usefulness of G-CSF for opportunistic pyelonephritis. We prepared three groups of experimental pyelonephritis, i.e., G-CSF administration group (group-1), cyclophosphamide (CPA) administration group (group-2), and CPA and G-CSF administration group (group-3). And we measured the active oxygen generation of peritoneal macrophages and PMNs in each group. On the other hand, we produced pseudomonal pyelonephritis in each group, and compared the survival rate of each group for 7 days. G-CSF enhanced active oxygen generation of peritoneal macrophages and PMNs, significantly. Furthermore, G-CSF improved the survival rate of pseudomonal pyelonephritis in leukocytopenic rats. These results indicate that G-CSF enhanced bactericidal activities of macrophages and PMNs in vivo, and prevents dissemination of infections.

Influence of Granulocyte Colony-Stimulating Factor on Bactericidal Activities of Macrophages and Polymorphonuclear Leukocytes