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Articular cartilage is a specialized tissue with a restricted capacity for self-repair. Thus, there is a need for a functional tissue replacement product for cartilage due to the ever-increasing occurrence of cartilage injuries and osteoarthritis. Engineering a cartilage replacement construct entails a combination of source cells, cytokines/growth factors, differentiation factors, and a supportive structure to mimic the native environment [1]. An abundant source of cells, isolated from adult bone marrow, are mesenchymal stem cells (MSCs), which when isolated can be a rich cell source given their capacity for chondrogenic differentiation [2].Copyright © 2010 by ASME

Effect of Mechanical Stimulation on Mesenchymal Stem Cell Seeded Cartilage Constructs