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Hyaluronic acid is a commonly used natural polymer for cell scaffolding. Modification by methacrylate allows it to be polymerized by free radicals via addition of an initiator, e.g. light-sensitive Irgacure, to form a methacrylated hyaluronic acid (MeHA) hydrogel. Light activated crosslinking can be used to control the degree of polymerization, and sequential polymerization steps allow cells plated onto or in the hydrogel to initially feel a soft and then a stiff matrix. Here the elastic modulus of MeHA hydrogels were systematically analyzed by atomic force microscopy for a number of variables including duration of UV exposure, monomer concentration, and methacrylate functionalization. To determine how cells would respond to a specific two-step polymerization, NIH 3T3 fibroblasts were cultured on the stiffening MeHA hydrogels and found to reorganize their cytoskeleton and spread area upon hydrogel stiffening, consistent with cells originally cultured on substrates of the final elastic modulus.

Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel