English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Study of the inhibitory effect of Salvia scutellarioides extracts on the activity of the angiotensin-converting enzyme. Objective. To identify groups of secondary metabolites of Salvia scutellarioides present in the fraction with the greatest inhibitory effect on the activity of the angiotensin-converting enzyme (ACE). Materials and methods. Dry plant material was used to prepare ethanolic extracts that were then concentrated and separated by column chromatography using solvents of different polarity (petroleum ether, dichloromethane , diethyl ether and ethanol). Subsequently, lung tissue isolated from Wistar rats was broken and centrifuged in order to separate the sol uble material. Proteins found in the supernatant were separated using a Sephacryl column; a pool was made with the fractions that showed activ ity with hippuryl-L-histidyl-L-leucine (HHL), the substrate of the ACE. This enzyme extract was used to measure the effect of plant ext racts obtained from S. scutellarioides on the ACE activity. Results: The fraction of ethyl acetate (T2) showed a greater inhibitory effect on the ACE activity. Metabolites found in T2 fraction were: tannins, cardiac glycosides, coumarins, and quinones. Conclusion. An antihypertensive effect was found for the plant species Salvia scutellarioides by studying the inhibitory effect on the ACE activity. Several groups of secondary metabolites present in the T2 fraction were identified, which could be responsible for this effect.

Estudio del efecto inhibitorio de extractos de Salvia scutellarioides sobre la actividad de la enzima convertidora de angiotensina