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Antimicrobial-guided fractionation and isolation of the bioactive compounds from the stem bark of D rimys arfakensis Gibbs. were carried out. Two antimicrobial compounds were isolated. The sructures of the compounds were elucidated by spectroscopic methods such as 1 H NMR, 13 C NMR, 2-D NMR, ESI-MS and EI-MS. Based on the spectroscopic data, the two antimicrobial compounds were polygodial, 1 and and 11-Hydroxydrim-8-en-7-one, 2 . . Compound 1 exhibited very strong activity against methicillin-resistant Staphylococcus aureus (MRSA) (B-1823), and yeast-like fungi Candida albicans (B-2219) with both having MIC values of  7.8 µg.mL -1 .  It also showed strong activity against gram negative bacteria Escherichia coli (B-1634 ) with MIC value of 31.2 µg.mL -1 . While compound 2 only possesses strong activity against S. aureus (MRSA), no activity against C. albicans and E. coli was observed. This is the first report on the antimicrobial activity of compound 2 and on the isolation of these two compounds from D. arfakensis Gibbs.

malaysian journal of fundamental and applied sciences

Two antimicrobial compounds drimane sesquiterpene polygodial and 11-hydroxydrim-8-en-7-one from the stem bark of Drimys arfakensis Gibbs. (Winteraceae)