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Objective  The study aims to know the effect of electroacupuncture ( EA ) in maintenance of the homeostasis of the neuroendocrine system in hepatectomy rats and the involvement of arginine vasopressin ( AVP ) signaling in hypothalamus after  EA  was observed.    Materials and Methods  Rats were randomly assigned to four groups, including the intact group, model group, sham‐ EA  group, and  EA  group.  EA  was given during the perioperative period at the  Z usanli ( ST36 ) and  S anyinjiao ( SP6 ) points after hepatectomy. The serum adrenocorticotropic hormone ( ACTH ) and corticosterone ( CORT ) levels were detected via radioimmunoassay. The expression of  AVP , arginine vasopressin receptor 1a ( AVPR1a ), arginine vasopressin receptor 1b ( AVPR1b ), and glucocorticoid receptor ( GR ) was detected by Western blot after surgery.    Results  Compared with the intact group, the  ACTH  and  CORT  levels in the serum of model group were increased, whereas the  ACTH  and  CORT  levels were decreased in the  EA  group compared with the model group. Moreover,  AVP  and  AVPR1b  protein levels in the pituitary gland were increased in the model group and decreased in the  EA  group. Further, a distinct increase in the  AVP  and  AVPR1a  protein levels was observed in the model group, whereas they were significantly decreased in the  EA  group. Blockade of  AVPR1b  by nelivaptan reduced the increase of  ACTH  and  CORT .  D  [ L eu 4 ,  L ys 8 ] vasopressin can inhibit the effect of  EA  in rectification of the hyperactivity of the hypothalamic‐pituitary‐adrenal ( HPA ) axis.    Conclusions   EA  application at  ST36  and  SP6  can ameliorate the hyperactivity of the  HPA  axis via  AVP  signaling during the perioperative period.

neuromodulation: technology at the neural interface

Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture‐Attenuated Hypothalamic‐Pituitary‐Adrenal Axis Hyperactivity in Hepatectomy Rats