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Objectives  To validate the enhanced therapeutic effect of  Salvia miltiorrhiza  Bunge ( SM ) for brain ischemic stroke through the anti‐apoptotic and survival ability of mesenchymal stem cells ( MSC s).    Methods  The viability and the expression level of cell apoptotic and survival‐related proteins in  MSC s by treatment of  SM  were assessed  in vitro . In addition, the infarcted brain region and the behavioural changes after treatment of  MSC s with  SM  were confirmed in rat middle cerebral artery occlusion ( MCA o) models.    Key findings  We demonstrated that  SM  attenuates apoptosis and improves the cell viability of  MSC s. In the rat  MCA o model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of  MSC s with  SM .    Conclusions  The therapy using  SM  enhances the therapeutic effect for brain ischemic stroke by promoting the survival of  MSC s. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell‐based therapies for patients suffering from a variety of diseases.

Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions