Open AccessSalvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions
Author(s) -
Kim Ran,
Lee Seokyeon,
Lee Chang Youn,
Yun Hwayoung,
Lee Hojin,
Lee Min Young,
Kim Jongmin,
Jeong JeeYeong,
Baek Kyungmin,
Chang Woochul
Publication year - 2018
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/jphp.12950
Subject(s) - salvia miltiorrhiza , mesenchymal stem cell , apoptosis , medicine , stroke (engine) , viability assay , therapeutic effect , pharmacology , ischemic stroke , cell , ischemia , traditional medicine , traditional chinese medicine , pathology , biology , biochemistry , mechanical engineering , alternative medicine , engineering
Objectives To validate the enhanced therapeutic effect of Salvia miltiorrhiza Bunge ( SM ) for brain ischemic stroke through the anti‐apoptotic and survival ability of mesenchymal stem cells ( MSC s). Methods The viability and the expression level of cell apoptotic and survival‐related proteins in MSC s by treatment of SM were assessed in vitro . In addition, the infarcted brain region and the behavioural changes after treatment of MSC s with SM were confirmed in rat middle cerebral artery occlusion ( MCA o) models. Key findings We demonstrated that SM attenuates apoptosis and improves the cell viability of MSC s. In the rat MCA o model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of MSC s with SM . Conclusions The therapy using SM enhances the therapeutic effect for brain ischemic stroke by promoting the survival of MSC s. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell‐based therapies for patients suffering from a variety of diseases.