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A 22-year-old soldier presented with vivax malaria after extended travel in Afghanistan. Compliant with atovaquone/proguanil in country, he discontinued prophylaxis immediately upon departure. This case raises important issues regarding prophylactic choice and compliance during travel to Plasmodium vivax endemic locations and primaquine's registration status for prophylaxis and use by practitioners.

Relapsing Vivax Malaria After 6 Months of Daily Atovaquone/Proguanil in Afghanistan: The Case for Expanded Use of Primaquine as a Causal Prophylactic