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Gianotti‐Crosti syndrome‐like reaction to molluscum contagiosum–Clinical characteristics and response to treatment
Author(s) -
Bürgler Christina,
Weibel Lisa,
SchwiegerBriel Agnes,
Knöpfel Nicole,
Luchsinger Isabelle,
Theiler Martin
Publication year - 2021
Publication title -
jddg: journal der deutschen dermatologischen gesellschaft
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 60
eISSN - 1610-0387
pISSN - 1610-0379
DOI - 10.1111/ddg.14608
Subject(s) - medicine , dermatology , molluscum contagiosum , rash , retrospective cohort study , surgery
Summary Background and objectives Molluscum contagiosum (MC) is a common viral infection. Hypersensitivity reactions reminiscent of Gianotti‐Crosti syndrome, termed Gianotti‐Crosti syndrome‐like reaction (GCLR), have been reported in a subset of patients. We report a series of patients with GCLR, better delineating its clinical presentation and course. Patients and methods Retrospective chart review of all children presenting with GCLR at our Pediatric Skin Center between 2015 and 2020. Results 26 children (14 boys) with a median age of 6.5 (3–11.3) years were included. GCLR involved the extensor surfaces of the extremities in all patients. More widespread eruptions also affected the trunk and face in 7 (27 %) and 6 (23 %) children respectively. Involvement of the skin overlying the Achilles tendons was a new finding in 4 (15 %) children. Itch was the predominant symptom in 20 (77 %) patients. The rash responded to topical and/or systemic corticosteroids and resolved within four weeks. GCLR was followed by clearance of MC in all patients within 9 (4–24) weeks. Conclusions GCLR is a characteristic acute, wide‐spread, pruritic papular eruption, which often leads to emergency consultations and anxiety in affected patients. GCLR responds well to corticosteroid treatment, has a benign course, and heralds the healing of MC.