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More and more studies propose that high frequency brain signals are promising biomarkers of epileptogenic zone. In this paper, our aim is to investigate the neuromagnetic changes and brain network topological alterations during an interictal period at high frequency ranges (80-1000 Hz) between healthy controls and epileptic patients with Magnetoencephalography. We analyzed neuromagnetic activities with accumulated source imaging, and constructed brain network based on graph theory. Neuromagnetic activity changes and brain network alterations between two groups were analyzed in three frequency bands: ripple (80-250 Hz), fast ripples (FRs, 250-500 Hz), and very high frequency oscillations (VHFO, 500-1000 Hz). We found that epileptic patients showed significantly altered patterns of neuromagnetic source localization and altered brain network patterns. And, we also found that mean functional connectivity and the number of modules from epileptic patients significantly increased in the ripple and FRs bands, and mean clustering coefficient from epileptic patients significantly decreased in the ripple and FRs bands. We also found that the mean functional connectivity was positively correlated with duration of epilepsy in the ripple and VHFO bands, and the number of modules was positively correlated with the duration of epilepsy in the ripple, FRs, and VHFO bands. Our results indicate that epilepsy can alter patients' neuromagnetic activities and brain networks in the high-frequency ranges, and these alterations become more pathological as the duration of epilepsy grows longer.

ieee transactions on neural systems and rehabilitation engineering

A Magnetoencephalography Study of Pediatric Interictal Neuromagnetic Activity Changes and Brain Network Alterations Caused by Epilepsy in the High Frequency (80–1000 Hz)