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We are currently investigating the feasibility of using highly pixelated Cadmium Zinc Telluride (CdZnTe) detectors for sub-500 &#x03BC;m resolution PET imaging applications. A 20 mm &#x00D7; 20 mm &#x00D7; 5 mm CdZnTe substrate was fabricated with 350 &#x03BC;m pitch pixels (250 &#x03BC;m anode pixels with 100 &#x03BC;m gap) and coplanar cathode. Charge sharing among the pixels of a 350 &#x03BC;m pitch detector was studied using collimated 122 keV and 511 keV gamma ray sources. For a 350 &#x03BC;m pitch CdZnTe detector, scatter plots of the charge signal of two neighboring pixels clearly show more charge sharing when the collimated beam hits the gap between adjacent pixels. Using collimated Co-57 and Ge-68 sources, we measured the count profiles and estimated the intrinsic spatial resolution of 350 &#x03BC;m pitch detector biased at -1000 V. Depth of interaction was analyzed based on two methods, i.e., cathode/anode ratio and electron drift time, in both 122 keV and 511 keV measurements. For single-pixel photopeak events, a linear correlation between cathode/anode ratio and electron drift time was shown, which would be useful for estimating the DOI information and preserving image resolution in CdZnTe PET imaging applications.

3-D Spatial Resolution of 350 /spl mu/m Pitch Pixelated CdZnTe Detectors for Imaging Applications