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<italic>Objective:</italic> We present Myolink, a portable, modular, low-noise electrophysiology amplifier optimized for high-density surface electromyogram (HD sEMG) acquisition. <italic>Methods:</italic> Myolink consists of 4 modules. Each 10 × 8 cm module can concurrently acquire 32 unipolar electrode potentials at sampling rates of up to 8 kHz with 24-bit resolution. Modules may be stacked and operated synchronously, supporting the concurrent acquisition of up to 128 channels. A custom high-performance analog front-end provides an input-referred-noise <inline-formula><tex-math notation="LaTeX">$\mathbf {< 0.4}$</tex-math></inline-formula> <inline-formula><tex-math notation="LaTeX">$\mu \mathbf {V}_{\mathbf {RMS}}$</tex-math></inline-formula> for a bandwidth of 23–524 Hz (tuneable by design choices), which is lower than current commercial systems. Digitized signals are processed by a custom on-board FPGA-based controller and subsequently transmitted to a PC via a medical-grade isolated USB 2.0 interface. <italic>Results:</italic> The system has been tested by recording experimental HD sEMG signals, which have been subsequently decomposed into motor unit action potentials. Compared to commercially available systems, the proposed recording system led to higher-quality surface EMG acquisition, as well as higher decomposition accuracy across a wide range of forces, with the greater gain for forces <inline-formula><tex-math notation="LaTeX">$\leq$</tex-math></inline-formula> 20% of the maximum voluntary contraction. <italic>Significance:</italic> A portable, ultra-low-noise, HD sEMG amplifier design has been implemented and characterized. The system provides IRN performance beyond the capabilities of current state-of-the-art instrumentation and this improvement has a significant effect on HD sEMG decomposition.

ieee transactions on biomedical engineering

Myolink: A 128-Channel, <inline-formula><tex-math notation="LaTeX">$\text{18 nV}/\sqrt{\text{Hz}}$</tex-math></inline-formula>, Embedded Recording System, Optimized for High-Density Surface Electromyogram Acquisition

Myolink: A 128-Channel, $\text{18 nV}/\sqrt{\text{Hz}}$, Embedded Recording System, Optimized for High-Density Surface Electromyogram Acquisition