English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Pro

Presents the zaia usage as premium feature

ZAIA

Presents AI Discovery search usage as a premium feature

AI Discovery

Presents AI Discovery explain and summary usage as a premium feature

Content Analysis

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Presents the pdf analysis as premium feature

PDF Analysis

1500 Top-up

3000 Top-up

Zendy Basic

2500 Top-up

Zendy Unlimited

Presents the access of premium content as premium feature

Premium Content

A semi-empirical model was applied to estimate the frequency shift of a shear-horizontal surface-acoustic-wave (SH-SAW) biosensor for detecting a disease-related biomarker antigen transferrin receptor (CD71) in the sample. In the simulation to investigate its sensitivity, a shift of the SH-SAW resonant frequency occurred by applying an incremental surface mass density change on the surface. The semi-empirical model was proposed and developed by using the experimental and numerical results to relate the concentration of the biomarker to the frequency shift. Results indicated that the thickness of the SiO2 guiding layer affects the sensitivity of SH-SAW sensing, and the dependence is non-monotonically. The SH-SAW sensor was used for specific detection of biotin at a varied concentration. With the concentration of the targeted antigen in the range 0.4 &#x223C;4.2 &#x03BC;g&#x002F;mL, a typical exponential relation was found between the quantitative target and the frequency shift. Measurement results showed that the mass-loading effect of the antibody-antigen has a reliable response with a sensitivity of 0.94 kHz&#x002F;(&#x03BC;g&#x002F;mL). Effects of the sample flow rate on the antigen- antibody interaction and thus the frequency shift of the SH-SAW sensor were also evaluated. It is demonstrated that the proposed model provides a useful approach to analyze effectively the frequency shift dependence on the concentration and the flow rates of sensed molecules in a flow-type SH-SAW sensor.

Detection of Transferrin Receptor CD71 on a Shear Horizontal Surface Acoustic Wave Biosensor