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Magnetic Resonance Imaging (MRI) is a non-invasive tool for the clinical assessment of low-prevalence neuromuscular disorders. Automated diagnosis methods might reduce the need for biopsies and provide valuable information on disease follow-up. In this paper, three methods are proposed to classify target muscles in Collagen VI-related myopathy cases, based on their degree of involvement, notably a Convolutional Neural Network, a Fully Connected Network to classify texture features, and a hybrid method combining the two feature sets. The proposed methods were evaluated on axial T1-weighted Turbo Spin-Echo MRI from 26 subjects, including Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy patients at different evolution stages. The hybrid model achieved the best cross-validation results, with a global accuracy of 93.8%, and F-scores of 0.99, 0.82, and 0.95, for healthy, mild and moderate/severe cases, respectively.

Severity Classification in Cases of Collagen Vi-Related Myopathy with Convolutional Neural Networks and Handcrafted Texture Features