English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Grid structures are common in high-throughput assays to parallelize experiments in biochemical or biological experiments. Manual analysis of grid images is laborious, time-consuming, expensive, and critical in terms of reproducibility. However, it is still common to do such analysis manually, as there is no standardized software for automated analysis. In this paper, we introduce a generic method to automatically detect grid structures in images and to perform flexible spot-wise analysis after successful grid detection. The deep learning-based approach of the grid structure detection allows being flexible concerning different grid types. The combination with a robust parameter estimation algorithm lowers the requirements of the detection quality and thus enhances robustness. Further, the method conducts semi-automated grid detection if a fully automated processing fails. An open-source software tool Grid Screener that implements the proposed methods is provided as a ready-for-use tool for researchers. The usability is demonstrated by taking different criteria into account, which are important for a successful application. We present the benefits of our proposed tool Grid Screener utilizing three different grid types in the context of high-throughput screening to show our contribution towards further lab automation. Our tool performs much faster than manual analysis, while maintaining or even enhancing accuracy.

Grid Screener: A Tool for Automated High-Throughput Screening on Biochemical and Biological Analysis Platforms