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Cardiovascular related diseases are the most significant health concern around the globe. The most crucial health indicator is blood pressure because it gives essential information about the health of a patient&#x2019;s heart. Cardiovascular diseases can be detected early and prevented if blood pressure is monitored continuously and regularly. Blood pressure cuffs, which are widely used to control blood flow in the arm or wrist when measuring blood pressure, are not practical for continuous blood pressure measurement. However, biosignals can be used for blood pressure estimation; but it is still critical and challenging. In this paper, we conducted a comprehensive analysis of feature extraction techniques for blood pressure estimation by using PPG signals. The feature extraction techniques were further divided into three subgroups to analyse the significance of each group. Group A includes time-based features; group B presents statistical feature extraction, and group C presents frequency domain-based features. The analysis employed several machine learning algorithms and compared their performance from many perspectives. The experimental results from two publicly available datasets demonstrated that the set of features belonging to group A were more reliable than other techniques for blood pressure estimation. We found that deep learning models achieved better performance than all traditional machine learning methods. We also found that the GRU model and Bi-LSTM achieved the best performance for time-domain features for blood pressure estimation. We believe the findings of this benchmark study will help researchers choose the most appropriate method for feature extraction and machine learning algorithms.

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A Benchmark Study of Machine Learning for Analysis of Signal Feature Extraction Techniques for Blood Pressure Estimation Using Photoplethysmography (PPG)