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The human brain undergoes tremendous changes during the first decade of life. The susceptibility of the immature central nervous system to factors such as adverse environments and genetic factors is attributed to its plasticity. Neurodevelopmental disorders (NDDs) occur once the immature brain veers off the typical developmental trajectory. However, little is known about the neurophysiological traits of atypically developing children because it is challenging for them to remain still during recording. Magnetoencephalography (MEG) is a noninvasive neuroimaging technique with high-spatiotemporal resolution. An ultralow magnetic field produced by neural electrical activity can be detected using a highly sensitive whole-head magnetometer array. Current cryogenic SQUID-MEG combined with individual MRI has shown great potential in reflecting neural activity under resting states and during tasks. MEG instrumentation for children is expected to be an effective tool for investigating brain dynamics, which provides neuropsychological evidence for atypical development in communication ability. In this paper, the advantages of pediatric MEG in neurodevelopmental disorder studies are discussed first and compared with those of several noninvasive functional imaging modalities. Existing commercial pediatric MEG systems are summarized based on their respective characteristics and parameters. State-of-the-art newly emerging sensing techniques based on spin-exchange relaxation-free (SERF) along with their application in detecting infants' brain responses are introduced. Recent discoveries on MEG biomarkers in children with NDDs are then summarized concerning disorders that have comorbidities in communication, such as specific language impairment (SLI), autism spectrum disorders (ASD), dyslexia and stuttering. Progress on multimodality research and total-field wearable SERF magnetometers offers insight into the neuropsychological substrates of communication disorders.

Whole-Head Magnetoencephalogram and Its Application in Developmental Communication Disorders Research: A Review